This blog is dedicated to my good friend Christine, who does not have a
favorable experience with alcohol. She finds that when she just has one drink
she becomes flushed, feels bad, and will become sick if she drinks more than
two drinks within a few hours. I, on the other hand, (not that I have ever
tried this), can consume a large quantity of alcohol in a short period of time
and not experience any symptoms of being drunk. People are often amazed by this
phenomenon, considering I am a small female who doesn’t drink a lot; so one
would assume I cannot handle my alcohol.
WARNING: Super Sciency terms for the following paragraph:
Did you know that your genetics may play a huge role in how quickly you
get drunk and how you metabolize alcohol? There is some truth to those college
kids who say “I’m Irish so I can drink a lot!” Certain Asian populations,
specifically East Asians such as the Han Chinese, Taiwanese and Japanese, have
polymorphisms of the alleles involved in the enzymes used to metabolize
alcohol. For alcohol to be metabolized, it must be converted from ethanol
(alcohol) to acetylaldehyde, then acetylaldehyde to acetic acid. Alcohol
dehydrogenase(ADH) is the enzyme used
for ethanol -> acetylaldehyde and acetylaldehyde dehydrogenase (ALDH) is the
enzyme used for the second step. About 50% of people with Asian ancestry
experience a mutated ALDH enzyme, which leads to an accumulation of
acetylaldehyde. This build up causes facial flushing, increased heart rate, and
an increased skin temperature after alcohol is ingested.
In addition to the specific mutations common in Asians that limit their
ability to consume alcohol, certain populations have higher rates of alcohol
elimination, which allows for more alcohol to be consumed without experiencing
immediate negative consequences. Certain countries in Europe, such as Ireland,
England, Germany, and Russia drink more than other countries, and some experts
believe that is due to their normal ALDH enzymes and higher rates of alcohol elimination
and metabolism.
Besides ancestry, body water percentage tends to play a huge role in the
ability to metabolize alcohol. Body fat has low water content, whereas lean
muscle is mostly water. Women tend to have “lower” tolerances because they
have, on average, more body fat than men. Older people tend to have lower
tolerances because they have less water (due to decreased muscle mass). So, you theoretically will have the highest
tolerance if you are a young and very lean man who is well hydrated.
My recommendations: No alcohol is good for you; in fact, it is
toxic to the body. Alcohol is very calorie dense (7 cal/gram compared to 4
cal/gram for fat and carbs), and is an easy way to add hundreds of useless
calories to your daily intake. However, this blog was meant to be more
entertaining and informative....so, if you’re looking to increase your alcohol metabolism perhaps you should hit the gym and start eating healthy! ;-)
My conclusion about why I can drink more is because I am of Eastern European and Irish heritage, I am pretty lean, still relatively young, and am always well hydrated.
References:
3. Edenberg
HJ, Jerome RE & Li M (1999) Polymorphism of the human alcohol dehydrogenase
4 (ADH4) promoter affects gene expression. Pharmacogenetics 9, 25–30.
4. Proceedings
of the Nutrition Society (2004), 63, 49–63
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